Gastrointestinal (Upper) Cancer Surgeon

Oesophago-gastric, hepatobiliary and pancreatic cancers

Approximately 3,000 people are diagnosed with a primary oesophago-gastric, hepatobiliary or pancreatic cancer in Scotland every year.

Common symptoms of oesophago-gastric cancer include weight loss, dysphagia, heartburn or pain, vomiting and anaemia. Common symptoms of hepatobiliary or pancreatic cancer include jaundice, abdominal mass, epigastric pain and weight loss. The risk of developing an oesophago-gastric cancer is higher in patients of East Asian origin and a higher suspicion of risk should be used in these patients.

An abdominal examination and appropriate blood tests (for example, full blood count, ferritin, urea and electrolytes test [U&Es] and liver function tests [LFTs]) should be performed on all patients with symptoms suggestive of these cancers. These findings can facilitate triage in secondary care. Referral should not be influenced by Helicobacter pylori (H pylori) status. Proton pump inhibitors should be avoided if possible prior to investigation. H2 antagonists may be used for symptomatic relief.

All patients with high-risk features should be referred to a team specialising in the management of oesophago-gastric, hepatobiliary or pancreatic cancers, depending on local arrangements.

Urgent suspicion of cancer referral

Oesophago-gastric cancer

Dysphagia (interference of the swallowing mechanism that occurs within 5 seconds of the swallowing process) or odynophagia (pain on swallowing) at any age.

New onset upper gastrointestinal pain or discomfort in people over 55 years.

New or worsening upper gastrointestinal pain or discomfort combined with one or more of the following features:

  • unexplained weight loss
  • unexplained iron deficiency anaemia

Persistent vomiting more than 4 weeks.

Upper gastrointestinal pain or discomfort combined with at least one of the following risk factors:

  • family history of oesophago-gastric cancer in more than two first-degree relatives
  • family history of familial adenomatous polyposis in any first-degree relative
  • Barrett’s oesophagus
  • pernicious anaemia
  • gastric surgery over 20 years ago
  • known dysplasia, atrophic gastritis or intestinal metaplasia
Hepatobiliary and pancreatic cancer

Features of hepatobiliary or pancreatic cancer can be vague and non-specific, and may include:

  • unexplained obstructive jaundice
  • upper abdominal or epigastric mass
  • unexplained back pain (consider other cancer causes such as malignant spinal cord compression)
  • unexplained weight loss
  • any suspicious abnormality, in the hepatobiliary tract, found on imaging (such as biliary dilatation or pancreatic/liver lesion)

Primary care management

Dyspepsia under 55 years without accompanying symptoms or risk factors should be managed according to local or national guidelines.

Good Practice Points

There should be a low threshold for considering investigation (perhaps with discussion about appropriate imaging with a radiologist) or routine referral for patients presenting with:

  • late onset diabetes in a weight-losing patient
  • non responsive dyspepsia following initial test and treat
  • post prandial pain or early satiety
  • new onset irritable bowel syndrome symptoms in middle age
  • steatorrhoea or fat malabsorption


Reference:
Scottish Referral Guidelines for Suspected Cancer. Scottish Government, August 2014
SIGN Guideline 87 – Management of oesophageal and gastric cancer
Clinical Lead Mr Hakim BenYounes, Chief of Medical Services, NHS Lanarkshire
Review Date March 2017

Colorectal, Suspicion of Cancer Referral

Lower Gastrointestinal Cancer

Lower gastrointestinal symptoms are common presentations in primary care. Rectal bleeding for instance is estimated to affect 14,000 individuals per 100,000 population each year. There are large differences in the predictive value of rectal bleeding for cancer according to its association with other symptoms and signs and the age of the patient. For example, the positive predictive value of rectal bleeding alone is 2.4%, which rises to 8.5% in combination with an abnormal rectal examination.

Different management strategies should be adopted according to cancer risk so that those patients with transient lowrisk symptoms caused by benign disease avoid unnecessary investigation. The following guideline is recommended for managing patients with features associated with a possible diagnosis of colorectal cancer. Guidance for referral to regional genetics centres for those with a family history of colorectal cancer is available available at Scottish Government Health and Social Care website. In patients with ulcerative colitis, a plan for follow up should be agreed.

An abdominal and rectal examination and a full blood count should be performed on all patients with symptoms suggestive of colorectal cancer. These findings can facilitate appropriate triage in secondary care. A negative rectal examination, or a recent negative faecal occult blood result, should not rule out the need to refer. The carcinogenic embryonic antigen (CEA) test should not be used as a screening tool. 
High-risk features
Urgent suspicion of cancer referral
BleedingRepeated rectal bleeding without an obvious anal cause
Any blood mixed with the stool
Bowel HabitPersistent change in bowel habit especially to looser stools (more than 4 weeks)
MassRight-sided abdominal mass
Palpable rectal mass
Iron deficiency anaemia
In men of any age with unexplained iron deficiency anaemia and a haemoglobin of 11g/100ml or below.
In non-menstruating women with unexplained iron deficiency anaemia and a haemoglobin of 10g/100ml or below.
Unexplained iron deficiency anaemia
OtherPast history of lower gastrointestinal cancer with any of the symptoms above

 

Primary care management

Low-risk features

  • Transient symptoms (less than 4 weeks)
  • Patients under 40 years in absence of high-risk features

Watch and wait (4 weeks)

  • Assessment and review
  • Consider bowel diary
  • Appropriate information, counselling and agreed plan for review with GP

Refer if symptoms persist or recur


Reference:
Scottish Referral Guidelines for Suspected Cancer. Scottish Government, August 2014
SIGN Guideline 126 – Diagnosis and Management of Colorectal Cancer
Lead Clinician Mr A Brown, NHS Lanarkshire
Review Date March 2017

Breast, Suspicion of Cancer Referral

Breast Cancer

Breast symptoms are a relatively uncommon presentation in primary care. It is estimated that between 0.35% and 0.6% of all consultations in Scotland are for breast symptoms. Many of these consultations will be in young women, whereas the biggest risk factor, after gender, is increasing age. Incidence of breast cancer in women aged 30-35 is 33 per 100,000 population and approximately 81% of breast cancers occur in women over the age of 50.

Breast cancer accounts for 30% of cancers in women and around 4,400 people are diagnosed with breast cancer in Scotland each year; approximately 20 of these are men. The following recommendations seek to improve the referral and effective management of breast symptoms in women and men in primary care. Guidance for referral to regional genetics centres for those with a family history of breast cancer is available at Health Improvement Scotland website.

Urgent suspicion of cancer referralRoutine ReferralPrimary care management
Issue relevant advice leaflet
LumpAny new discrete lump (in patients over 35 years)
New asymmetrical nodularity that persists at review after menstruation (in patients over 35 years)
Unilateral isolated axillary lymph node in women
Cyst persistently refilling or recurrent cyst
Any new discrete lump in patients under 35 years with no other suspicious features
New asymmetrical nodularity that persists at review after menstruation (in patients under 35 years)
Women with longstanding tender lumpy breast and no focal lesion
Tender developing breasts in adolescents
Nipple symptomsBloodstained discharge
New nipple retraction
Nipple eczema if unresponsive to topical steroids (such as 1% hydrocortisone) after a minimum of 2 weeks
Persistent discharge sufficient to stain outer clothes Transient nipple discharge which is not bloodstained
Check prolactin levels when discharge present
Longstanding nipple retraction
Nipple eczema if eczema present elsewhere
Skin ChangesSkin tethering
Fixation
Ulceration
Peau d'orange
Obvious simple skin lesions such as sebaceous cysts
Abscess/infectionMastitis or breast inflammation which does not settle after one course of antibiotics Abscess or breast inflammation even after settled in patients over 35 years Abscess* or inflammation - try one course of antibiotics to cover staphylococcus and streptococcus (also consider possible anaerobic infection as per local guidelines)
PainUnilateral persistent pain in post menopausal women
Intractable pain that interferes with the patient's lifestyle or sleep
Women with moderate degrees of breast pain and no discrete palpable lesion
GynaecomastiaExceptional aesthetics referral to plastic surgery pathway if required
Exclude or treat any endocrine cause prior to referral
Examine and exclude abnormalities such as lymphadenopathy or evidence of endocrine condition
Review to exclude drug causes
Measure hormones (oestrogen, testosterone, prolactin, human chorionic gonadotropin and alpha-fetoprotein)
Reassure

* Any acute abscess requires immediate discussion with secondary care.


Reference:
Scottish Referral Guidelines for Suspected Cancer. Scottish Government, August 2014
SIGN Guideline 134 – Treatment of Primary Breast Cancer
Clinical Lead Dr Juliette Mitchell, Consultant Surgeon, Wishaw General Hospital
Review Date March 2017


Suspicion of breast cancer dictation template